Mending the Failing Heart with a Vascularized Cardiac Patch
نویسندگان
چکیده
منابع مشابه
MenDing a Broken Heart: steM Cells anD CarDiaC repair
Cardiovascular disease (CVD), which includes hypertension, coronary heart disease (CHD), stroke, and congestive heart failure (CHF), has ranked as the number one cause of death in the United States every year since 1900 except 1918, when the nation struggled with an influenza epidemic. In 2002, CVD claimed roughly as many lives as cancer, chronic lower respiratory diseases, accidents, diabetes ...
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A growing body of evidence has shown that the heart is not terminally differentiated but continues to renew its cardiomyocytes even after the neonatal period. This new view of the heart increases hope for changing the strategy for treating cardiac injuries toward regenerative approaches. However, the magnitude and clinical significance of this process in homeostasis and disease and the underlyi...
متن کاملMending a Faltering Heart.
More people die every year from ischemic heart disease than any other disease. Because the human heart lacks sufficient ability to replenish the damaged cardiac muscles, extensive research has been devoted toward understanding the homeostatic and regenerative potential of the heart and to develop regenerative therapies for heart disease. Here, we discuss recent advances in the understanding of ...
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The pathophysiology of heart failure (HF) has long been linked to a neurohormonal imbalance because of excessive compensatory activation of the sympathetic nervous system (SNS). As HF develops, cardiac function is progressively lost prompting an increase in SNS activity in an attempt to maintain homeostasis and stabilize cardiac output. Although initially providing beneficial ionotropic support...
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The present study explores the possibility of local de novo aldosterone production in normal and failing hearts (human and mouse) and the regulation of such putative cardiac steroidogenesis. Total RNA was isolated from human tissue from failing hearts taken at the time of cardiac transplantation, from normal hearts obtained at autopsy, and from normal and pressure-overloaded mouse hearts. Vascu...
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ژورنال
عنوان ژورنال: Cell Stem Cell
سال: 2009
ISSN: 1934-5909
DOI: 10.1016/j.stem.2009.11.005